What is procyclidine

What is Procyclidine?

Procyclidine is a drug which belongs to anticholinergic group which works by blocking acetylcholine.

This in turn helps to decrease muscle stiffness, production of saliva, sweating and also helps to improve walking ability in people with Parkinson’s disease.

Procyclidine is used to treating symptoms of Parkinson’s disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol).

Anticholinergics can decrease severe muscle spasms of the back, neck, and eyes that are sometimes caused by psychiatric drugs.

It can also decrease other side effects such as muscle stiffness/rigidity (extrapyramidal signs-EPS). It  may worsen  movement problems caused by tardive dyskinesia.


Procyclidine IUPAC name

1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride


What is ProcyclidineChemical structure of Procyclidine


Procyclidine Brand Names

The Fllowing is a list of Procyclidine Brand Names :

  • EXTRANIL Procyclidine
  • Tablet KDRINE Procyclidine
  • Tablet KEMADRIN Procyclidine
  • Tablet PERKINIL Procyclidine

Procyclidine uses

Procyclidine is used to reduce the side effects of antipsychotic drugs given for the treatment of schizophrenia.

It is also used in patients with parkinsonism and akathisia and so procyclidine is also a second-line drug for the treatment of Parkinson’s disease. It improves tremor but not bradykinesia or rigidity.

Procyclidine is also sometimes used for the treatment of dystonia (but not tardive dyskinesia). Dystonia is a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

As procyclidine is an anticholinergic agent it works by relaxing smooth muscle, which stops muscle spasms.

Precautions with Procyclidine

If a person has angle closure glaucoma.

If you are allergic to any ingredient in procyclidine

DONOT take procyclidine or conntact your doctor or health care provider if any of these apply to you.

Other medical health issues which may interfere with this drug may be as follows

  • Pregnancy or planning to get pregnant
  • Breast feeding
  • If you are on any other medication
  • If you are taking any herbal preparations or dietary supplement
  • If you are allergic to any medication or foods
  • If you have glucoma
  • Mental or mood disorders
  • Muscle weakness like myasthenia gravis
  • Ulcerative colitis like enlarged prostate
  • Urination problems
  • Blockage of esophagus or stomach or urinary tract
  • Kidney or liver problems
  • High blood pressure
  • Heart or blood vessel disease
  • An irregular heartbeat
  • Uncontrolled movements of the hands, mouth, or tongue

What is ProcyclidineProcyclidine drug interactions

Some MEDICINES MAY INTERACT with procyclidine. Tell your doctor if you are taking any other medicines, especially any of the following:

Phenothiazines (eg, thioridazine) because the effectiveness may be decreased by procyclidine
Ask your doctor if procyclidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Procyclidine storage

  • Store of procyclidine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C).
  • Store away from heat, moisture, and light.
  • Do not store in the bathroom.
  • Keep procyclidine out of the reach of children and away from pets.

Procyclidine Overdose

Symptoms may include dilated pupils

  • fast breathing
  • fast heartbeat
  • Hot, dry or flushed skin.

This was in detail about what is procyclidine.